Bioactive Small Molecules
Medchemexpress LLC Crbn-6-5-5-vhl | 2362575-45-7 | MFCD32705129 | 99.5% | 972.20 | C51H69N7O10S | 5 MG
CRBN-6-5-5-VHL is a VHL-based proteolysis targeting chimera (PROTAC) for research use that induces selective degradation of cereblon (CRBN) in cellular assays. It demonstrates potent degradation activity (DC50 = 1.5 nM) with minimal effect on common neo-substrates, making it suitable for mechanism-of-action and targeted protein degradation studies.
- Potent cereblon degradation (DC50 = 1.5 nM).
- Selective activity with little effect on IKZF1 and IKZF3.
- High reported purity (99.45%).
- Suitable for in vitro and cellular degradation assays.
- Available in small-scale research quantities (e.g., 5 mg).
Cayman Chemical ANTIBODY Pyrazolam 10mg
An analytical reference standard categorized as a benzodiazepine; has been abused recreationally and has anxiolytic-like effects in mice; intended for research and forensic applications
Cayman Chemical ANTIBODY DnIrIxIn 1mg
A CXCR2 antagonist (IC50 = 12.5 µM); selective for CXCR2 over CXCR1 (IC50 = 977 nM); inhibits IL-8-induced calcium mobilization in CHO-K1 cells expressing human CXCR2 (pA2 = 7.52); inhibits neutrophil surface expression of CD11b in isolated rat whole blood (IC50 = 890 nM); reduces BALF neutrophil infiltration in rat models of LPS- or ozone-induced pulmonary neutrophilia (ED50s = 1.4 and 16 mg/kg, respectively)
Medchemexpress LLC BAM7 | 331244-89-4 | C21H19N5O2S | 50 MG
BAM7 is a direct and selective activator of proapoptotic BAX with an IC50 of 3.3 μM.
- Selective for the BH3-binding site on BAX
- Activates BAX and BAX-dependent cell death
- Stable under recommended storage conditions
- For research use only
Medchemexpress LLC Pterin | 2236-60-4 | MFCD01456481 | 99.8% | 163.14 g·mol⁻¹ | C6H5N5O | 25 MG
Pterin is a pteridine heterocycle provided as a high-purity research reagent for biochemical and medicinal chemistry applications.
- High purity (99.75%) for analytical and synthetic work.
- Molecular formula C6H5N5O and molecular weight 163.14 g·mol⁻¹.
- Available in small to mid scale pack sizes (25 mg-5 g) for flexible usage.
- Characterized by supporting data including COA, HNMR, LC-MS, and HPLC.
- Suitable as a reference standard or building block in research workflows.
Medchemexpress LLC BTTES | 1334179-86-0 | C19H32N10O4S | 50 MG
BTTES is a tris(triazolylmethyl)amine-based ligand for Cu(I) without apparent toxicity. It improves the cycloaddition reaction rapidly in living systems.
- Tris(triazolylmethyl)amine-based ligand for Cu(I)
- No apparent toxicity
- Improves cycloaddition reaction rapidly in living systems
Cayman Chemical ANTIBODY C-176 25mg
A STING inhibitor; reduces STING-, but not RIG-I or TBK1-, mediated IFN-β reporter activity in HEK293 cells from 0.01-5 μM; reduces serum levels of type-I IFNs and cardiac inflammation the in Trex-/- mouse model of multi-organ inflammation
Medchemexpress LLC L-Alanine, N-[(3α,5β)-3-hydroxy-24-oxocholan-24-yl]- | 1428095-28-6 | 97.4% | 447.65 | 25 MG
L-Alanine, N-[(3α,5β)-3-hydroxy-24-oxocholan-24-yl]- | 1428095-28-6 | 97.4% | 447.65 | 25 MG
Medchemexpress LLC CID 697851 | 312508-42-2 | C14H12N4OS | 5 MG
CID 697851 is a solid, light yellow to yellow compound that functions as an AddAB and RecBCD inhibitor. It offers IC50s of 13 and 33 nM, making it suitable for antibacterial research.
- Functions as an AddAB and RecBCD inhibitor
- Offers IC50s of 13 and 33 nM
- Suitable for antibacterial research
- High purity (99.49%)
- Solid appearance
- Color ranges from light yellow to yellow
Cayman Chemical ANTIBODY MLE-4901 10mg
An NK3 receptor antagonist; inhibits human liver microsomal CYP3A4/5 (apparent IC50s = 7.1 and 19.8 μM in midazolam 1'-hydroxylation and testosterone 6β-hydroxylation assays, respectively)
Medchemexpress LLC 1,1':4',1''-terphenyl | 92-94-4 | MFCD00003061 | 99.8% | 230.31 g/mol | C18H14 | 100 G
p-Terphenyl (CAS 92-94-4) is an aromatic hydrocarbon used as a research chemical, synthetic intermediate, and analytical reference. It has formula C18H14 and a molecular weight of 230.31 g/mol. Derivatives have reported anticancer and anti-inflammatory activity. The material is supplied as a powder with supporting analytical data and storage recommendations.
- Molecular formula C18H14 and molecular weight 230.31 g/mol.
- High purity, about 99.8% by HPLC.
- Supplied as a solid powder suitable for synthesis and analysis.
- Includes analytical documents such as COA, SDS, 1H NMR, and RP-HPLC.
- Recommended storage: powder at -20°C for long-term or 4°C for shorter-term storage.
Apexbio Technology LLC OLDA 105955-11-1 50mg
N-oleoyldopamine (OLDA CAS 105955-11-1) is a synthetic lipid amide formed by the conjugation of dopamine to oleic acid OLDA is recognized as an endogenous ligand for the transient receptor potential vanilloid 1 (TRPV1) channel where it acts as an agonist to induce channel activation Through TRPV1 modulation OLDA has been shown to influence physiological processes such as nociception and neurogenic inflammation This compound is frequently utilized in neuropharmacological research to investigate TRPV1-mediated signaling pathways and to explore endovanilloid function in pain sensation and related neurological disorders
Apexbio Technology LLC NF 449 627034-85-9 50mg
NF 449 (CAS 627034-85-9) is a potent and selective antagonist of purinergic P2X1 receptors displaying an IC50 of 0 28 nM in rat models This compound inhibits ATP-induced activation of P2X1 ion channels which are significant in platelet function In vitro studies demonstrate that NF 449 efficiently blocks P2X1-mediated responses with higher selectivity compared to P2Y1 and P2Y12 receptors In vivo NF 449 selectively suppresses P2X1-mediated platelet aggregation and thrombus formation without substantially affecting bleeding time at lower doses NF 449 serves as a valuable tool for investigating P2X1 receptor function and the role of platelet P2 receptors in thrombosis
Cayman Chemical ANTIBODY L-006 235 10mg
An orally bioavailable reversible inhibitor of cathepsin K (Ki(app) = 0.2 nM); selective for cathepsin K over cathepsins B, -L, and -S (Ki(app) = 1, 6, and 47 µM, respectively); inhibits degradation of bovine bone by isolated rabbit osteoclasts (IC50 = 5 nM); reduces loss of lumbar vertebral bone mineral density by 13.3% in ovariectomized rabbits at 10 mg/kg for 27 days; increases weight bearing, indicating analgesia, in a rat model of osteoarthritis pain at 100 mg/kg